NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)
They do not imply therapeutic, diagnostic, or clinical benefit
Allergic Reactions: While uncommon, some individuals may experience allergic reactions to the injection, which can include itching, rash, or difficulty breathing
A 2024 Diabetes, Obesity and Metabolism study on a small-molecule NNMT inhibitor found it dose-dependently limited body weight and fat mass gains, improved oral glucose tolerance and insulin sensitivity, and suppressed hyperinsulinaemia in obese mice (PMID 39161060) [6]
Tired of chugging energy drinks to stay fueled throughout the day
Published in vitro and animal-model research has examined NNMT inhibition in connection with several areas of scientific interest, including adipocyte metabolism, NAD pathway regulation, mitochondrial function, and cellular energy signaling
