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It is still preclinical, still mostly rodent, and still not translated to a human neurological trial, but it is mechanistically coherent across independent models

This is because B12 acts on the bone marrow to normalize red blood cell creation, and the life cycle of a red blood cell is 90 days

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In addition, REST is expressed in type 1 NSCs and type 2 intermediate progenitors and serve to repress the fate commitment of NSCs and the generation of neurons