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There was only 75% agreement that following exclusion of other causes of symptoms, patients who do not report relief of their symptoms with LT4 therapy should specifically be recruited for combination therapy trials (167)

The search is for a natural or synthetic origin which will possess less undesirable effects and can alternate/replace or reduce the need of present strategy HRT

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88 p53 also regulates several signaling pathways correlated with glycolysis suppression to inhibit glycolysis