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Aggregation induced by enzyme-responsive ligand plays a key role in facilitating the nanoparticles penetration in the bloodbrain barrier and enhances its retention time in brain tumors

MS@MnO 2 nanoparticles have enhanced chemodynamic therapy and activatable MRI functions for monitoring therapy due to the features of simultaneous acid-controlled Mn 2+ ion release and GSH depletion, revealing the tremendous potential of MnO 2 as a TME responsive multifunctional theranostic agent [93]

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