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In infants, pyridoxine deficiency can cause irritability, abnormallyacute hearing, and seizures, which are unresponsive to anticonvulsants but respond to pyridoxine supplementation ( A study performed by Yang and Wang in 2009 showed in-vivo study that pyridoxine can inhibit glutamate release from cerebrocortical synaptosomes by suppressing voltage-dependent Ca2+ entry

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Li D, Gao Q, Xu L, Pang S, Liu Z, Wang C, et al

Zheng X, Lu G, Yao Y, Gu W

Fortune, J

Complementary transcriptomic analyses reinforce this finding that genes involved in oxidative phosphorylation and mitochondrial metabolism are downregulated in PCOS granulosa cells compared to normal responders, supporting the hypothesis that defective bioenergetics and redox regulation underlie follicular insufficiency (58)