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Furthermore, oxidative stress in early development may contribute to the increased risk of neurodegeneration later in life, thus linking neurodevelopmental and neurodegenerative disorders (Litwa, 2022)

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27 Another study of 12,590 twins reveals that environment, lifestyle, and stochastic factors may also play more important roles than genetics in ACPA production while genetic factors are more responsible for the progression from ACPA-positive individuals to arthritis

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PMID: 16822960

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