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Through establishing an interleukin (IL)-1-stimulated chondrocytes, it was found that L-theanine could inhibit the nuclear factor kappa B (NF-B) pathway, thereby reducing the expression of proinflammatory factors, including cyclooxygenase-2 (COX-2), prostaglandin E2, inducible nitric oxide synthase, as well as NO, and protect the degradation of extracellular matrix (32)

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Other viruses Evidence also implicates rotavirus [8, 9], congenital rubella [10, 11], and certain adenoviruses [12] in the pathogenesis of the disease, although their role requires further validation