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doi:10.1016/j.mce.2016.03.015 250

Rho GTPase signaling at the synapse: implications for intellectual disability

Vitamin B12 injections have been known to reduce symptoms of depression, improve cognitive function, increase energy levels, help with sleep patterns and even reduce anxiety

These risks are not theoretical possibilities but actual documented cases that have appeared in medical literature

Beacuse of its importance as a source of NADPH for fatty acid synthesis, you would expect to find a high activity of the pathway in tissues that synthesise fatty acids: liver, adipose tissue and lactating mammary gland