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Mechanistic study has shown that PGC-1 plays an important role in the modulation of the UPR through coactivating ATF6, a well-characterized sensor in UPR, thus contributing to skeletal muscle adapt to exercise training

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As a result, W276 6.48 toggles to further induce significant displacement of F272 6.44 and the cytoplasmic segment of TM6, resulting in the activation of GHSR (Fig