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When a person quits smoking, he or she must face a typical withdrawal syndrome that begins after a few hours and becomes more acute with a peak between 24 and 48 hours later

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The data on snus is clearest, and in the European review, [33] which seemed motivated to emphasize any evidence for on-ramp effects, concluded, The Swedish data do not support the hypothesis that smokeless tobacco (i.e., Swedish snus) is a gateway to future smoking. [33]

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Nicotine addiction should be approached in a comprehensive manner, considering biological, psychological and social aspects