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The NAD + -salvage-pathway connection has positioned NNMT inhibition within the broader cellular-aging and sirtuin-pathway research framework, alongside NAD + precursors such as nicotinamide riboside and nicotinamide mononucleotide

Some of the roles that cyanocobalamin serves in the body include: Cofactor for methionine synthase and L-methymalonyl-CoA mutase