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Genetic variants in antioxidant enzymes and mitochondrial function genes may influence individual glutathione levels and oxidative stress susceptibility

Risk increases significantly after 2+ years of use Post-bariatric surgery patients gastric bypass removes or bypasses the sites of intrinsic factor production and B12 absorption People with autoimmune conditions pernicious anemia (anti-intrinsic factor antibodies) and autoimmune gastritis directly block absorption People with GI conditions Crohns disease (especially ileal involvement), celiac disease, SIBO, and chronic H

Rheumatoid Arthritis: An autoimmune disease that causes inflammation in the elbow joint lining, leading to chronic pain and swelling

It then combines with another protein called intrinsic factor to be absorbed in the small intestine

New Drug,1999, 17, 271-284 19

PLoS One 11 (9), e0162590