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The most used treatments are immunosuppressive drugs such as corticosteroids, calcineurin inhibitors, antioxidant supplements, and phototherapies

As anticipated, the resulting Km r , Sm r /Sp r mutant lacked the slr0236 + WT gene and retained the sll1545 + WT gene (Figure 1F, see the typical PCR DNA bands of slr0236 :Km r , sll1545 :Sm r /Sp r and sll1545 + chromosomes, and the absence of the slr0236 + chromosome)

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

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While free radicals are essential for certain physiological processes, such as cell signaling and immune defense, their overproduction can disrupt the delicate balance between oxidants and antioxidants, leading to oxidative stress