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Two common observations are: clumping (the peptide forms visible clumps or flakes that wont dissolve) and cloudiness (the solution looks milky or has fine particles)

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Importantly, inefficient elimination of mitochondria in red blood cell (RBC) precursors of sickle-cell disease patients results in mitochondrial retention in mature erythrocytes with consequent increased ROS generation and accelerated hemolysis [60, 61]