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2) Develop standardized, clinically applicable biomarkers: Establish a multi-tiered biomarker panel combining biofluid-based markers (e.g., plasma oxPCs and urinary ferroptosis-related miRNAs) and tissue-based spatial signatures (e.g., ACSL4/GPX4 expression ratio in PT cells)

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doi: 10.1007/s00018-005-4560-2