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[7] [9] Caution is advised in individuals with renal insufficiency or those on dialysis, as impaired clearance may increase the risk of accumulation and toxicity

Advances in peptide synthesis have allowed the development of complex preparations derived from various tissue extracts

In some embodiments, the otic formulation or composition comprises about 10% by weight of the cholesterol

Res., 36(1), 5865 (2019)

Breaks between cycles prevent the development of tolerance and allow for natural hormonal regulation

Once dissociated, you have free copper ions and free peptide fragments - neither as effective as the intact complex