doi:10.1007/s11064-013-1144-7 Clark A, Mach N
Baselga J, Zamagni C, Gomez P, Bermejo B, Nagai SE, Melichar B, et al
The other fission products, aldehydo-acids, remain attached to the glycerolipid precursors, and such 'oxidatively truncated lipids' can disrupt membranes to increase their permeability directly and through signalling actions
The mechanistic study demonstrated the capacity of these drugs to inhibit calmodulin-dependent Ca 2+ -ATPase and endocytic pathways essential for hyphal morphogenesis
The enzyme jasmonoyl isoleucine conjugate synthase 1 (JAR1) in the cytosol catalyses the final step, although at least one alternative enzyme to JAR1, designated GH3.10, is present in leaf tissue (but 12hydroxy-jasmonic acid is its preferred substrate)
IMD-0354 could disrupt the membrane localization of ASCT2 and attenuate mTOR signaling