Weight loss plateau lasting more than 4 weeks A plateau of 2 to 3 weeks is normal and does not require dose changes
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Important Notes Practical considerations for consistency and safety
This, in turn, alleviates neuroinflammation and depressive-like behaviors in chronic stress models, such as chronic unpredictable mild stress (Murck et al., 2021)
These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance
Dietary interventions The study implemented an IF regimen for the intervention group, allowing only non-caloric beverages during a 16-hour fasting period and unrestricted eating for 8 h
