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"Like fasting," it said, "colonic cleansing carries a risk of dehydration, electrolyte imbalance, impaired bowel function, and disruption of intestinal flora." Edzard Ernst, professor of complementary medicine at Exeter University, called the concept of detoxing both a scandal and "criminal exploitation of the gullible man" in a 2014 interview with the Guardian

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The risk of vascular calcification and atherosclerosis is also affected by the Leu allele of GPX1 SNPs [51, 52]