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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

The two peptides target complementary aspects of the aging process

72 These astrocytes maintain their interactions with local neurones, synapses, oligodendrocytes and vascular cells but may alter these interactions in accordance with context-specific reactive changes in molecular expression and functions

doi: 10.1001/archopht.119.7.1009

Moreover, we monitored the interactome of a 20-mer ASO carrying 2-F wings by fluorescence microscopy and SILACMS/MS (Supplementary Fig