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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
doi: 10.2337/diab.35.3.282
Choline Plays a crucial role in overall cardiovascular health by reducing the risk of atherosclerosis, as well as metabolizing hepatic cholesterol
Recent surgery
James Granneman and Otto Muzik for insightful comments regarding human BAT positron emission tomography studies
1 vial: 3 mL 2 vials: 6 mL 3 vials: 9 mL Alcohol Swabs: Two administration swabs per injection: one for the vial stopper and one for the injection site
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