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Since fundamental biochemical pathways evolved in the absence of molecular oxygen, most intracellular disulfides are rather transient and most cysteinyl residues are kept in a reduced state with the help of the thioredoxin or the glutathione/glutaredoxin system 7,63,77

doi: 10.1016/j.intimp.2022.108637 21 LiJGaoWZhaoZLiYYangLWeiWet al

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YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

Studies in rodents have also found that methylene blue can protect the brain from damage from brain injury

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