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It was previously believed that these mutations were permanent and persisted even after a person stopped smoking

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And when you have a large enough cohort, as we did in this study, we can see that theres a preference towards those stops in tumor suppressor proteins through the mutational processes. The study also identified other factors and processes responsible for creating large numbers of stop-gain mutations, which are also called nonsense mutations

As home to over 15 million smokers, Vietnam is one of the 15 top consumers of tobacco in the world

Archives of General Psychiatry 58(9):810-816