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Following intravenous administration, GL is metabolized by -D-glucuronidase in hepatic lysosomes to form 3-monoglucuronyl glycyrrhetinic acid (3MGA), which subsequently undergoes enterohepatic circulation (Figure 3)

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Currently, the sole treatment for cataracts is the surgical insertion of artificial lenses 2 , a procedure often unavailable in developing countries with less advanced medical systems

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Furthermore, the sesquiterpenoid -element inhibited TGF--stimulated fibroblast activation in the NRK49F cell line and the phosphorylation of JAK2/STAT3 and Smad3