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Moreover, free phenolic extract from rape BP possesses higher capabilities to defend body cells from aberrant melanogenesis than bound phenolic extract via the suppression of microphthalmia-associated transcription factor (MITF) and downregulation of cyclic adenosine monophosphate (cyclic adenosine monophosphate) while preventing the anti-tyrosinase and antioxidant pathways in vitro ( Givotia rottleriformis diminish the growth of skin cancer cells (human epidermoid carcinoma) (149) and restrain hepatitis C virus (HCV) which causes hepatocellular carcinoma and liver cirrhosis (150)

Additionally, to elucidate the potential pathways associated with the DEGs, KOBAS software was employed for enriching significant DEGs within the KEGG pathway 4 (Mao et al., 2005)

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