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While NGPs are all safer than combustible cigarettes, they deliver nicotine, the primary psychoactive ingredient, in doses and (in the case of e-cigarettes and heated tobacco products [HTPs]) in a manner that more closely resembles cigarettes than nicotine replacement therapy products (NRTs) such as gum and patches

Stuck gauze : The gauze can also become stuck to the extraction site, causing further irritation and potential damage to the healing tissue

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After aging tobacco treated with Bacillus megaterium , the content of most aroma constituents increased compared with that of naturally aged tobacco, and microbial agents effectively promote the degradation and transformation of tobacco constituents, shortening the aging period of tobacco by at least six months (Li 2008)

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