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This is backed by a summary of six randomized controlled trials done in humans: AOD9604 had no effect on serum IGF-1 levels, which confirms the hypothesis that AOD9604 does not act via IGF-1

Puts et al., 2017), which hampers the development of treatments

Int J Mol Sci 24(13):10532

In this review, we discuss the pipeline of obesity pharmacotherapies with focus on entero-pancreatic hormone-based molecules, and we evaluate the data from early and late phase clinical trials on their safety and efficacy on WL in people with and without T2D

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach

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