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For individuals, following a plant-based diet, fortified plant-based milk, and nutritional yeast can help bridge the gap

Some carry real health risk that differs by compound and by person

Seiwerth S et al

Both homocysteine and its reactive metabolite, homocysteine thiolactone, can damage blood vessels and other tissues, and even levels in the upper normal range are associated with increased allcause mortality Genetic variants can increase the risk of high homocysteine, depending on your intake of B vitamins and choline

[126] Cellular reprogramming [edit] Vitamin B 12 through its involvement in one-carbon metabolism plays a key role in cellular reprogramming and tissue regeneration and epigenetic regulation

PMID: 16456809