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As one of the most fundamental molecules in biochemistry, NAD+ participates in over 500 enzymatic reactions, serving as a critical electron carrier in the mitochondrial electron transport chain and as a substrate for key regulatory enzymes including sirtuins, PARPs (poly-ADP-ribose polymerases), and CD38

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During the study, patients were maintained on a variable regimen of sarcoidosis therapeutics by their physicians, including oral glucocorticoids