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In some embodiments, the lipid-based drug delivery formulation or composition is a phospholipid-based formulation or composition wherein the natural or synthetic phospholipid is phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, lysophospholipids, egg or soybean phospholipid, or a combination thereof

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Collectively, these OFF-to-ON switching strategies illustrate therapeutic approaches in which GSH acts as a biological trigger for selective activation of cytotoxic agents in the GSH-rich tumor microenvironment

doi: 10.3389/fphar.2025.1525529 Received 09 November 2024 Accepted 21 March 2025 Published 17 April 2025 Volume 16 - 2025 Edited by William Chi-Shing Tai, Hong Kong Polytechnic University, Hong Kong SAR, China Reviewed by Yanwen Chen, University of Pittsburgh, United States Yasmina Mohammed Abd-Elhakim, Zagazig University, Egypt Sara Taha Elazab, Mansoura University, Egypt Priyanka N

Glutathione, the master antioxidant of the body, fights free radicals