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It exhibits antioxidant and otoprotective activity in the cochlea by up-regulating the Nrf-2/HO-1 pathway, while down-regulating p53 phosphorylation.Notably, this action of FA exhibits a biphasic response: it is pro-oxidant at lower concentrations and antioxidant at higher concentrations (Paciello et al., 2020)

The anesthetic provides immediate pain relief, while the corticosteroid reduces inflammation, offering longer-lasting results

This work underscores the potential of host-directed therapeutics, in conjunction with antibiotics, to improve treatment outcomes

Among animal species, ICR mice demonstrated the largest effect size, accompanied by a concomitant reduction in heterogeneity [SMD = 3.27, 95% CI (2.75,3.80), p = 0.008, I 2 = 65.5%]

[4] [7] Based on the principle of the assay, G6PD activity testing can be classified as qualitative assay and quantitative assay

[9] It is on the World Health Organization's List of Essential Medicines