Inflammatory cytokines, especially Interleukin-6 (IL-6), induce the release of acute phase proteins by the liver [5]
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LaiMEGradyRWVacquerSPepeACartaMPBinaPet alIncreased survival and reversion of iron-induced cardiac disease in patients with thalassemia Major receiving intensive combined chelation therapy as compared to desferoxamine alone
Phase 2 dose-finding trial Published in The Lancet in 2021, this multicenter, randomized, double-blind trial tested cagrilintide doses ranging from 0.3 mg to 4.5 mg weekly in people with overweight or obesity
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Discussion Iron homeostasis is essential to maintain cardiac function, and dysfunction of iron metabolism has been implicated in various cardiovascular diseases (3538)