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This lack of efficacy may be attributed to the low plasma and sputum concentrations of NTZ and the high plasma protein binding of tizoxanide, the active metabolite of NTZ [80], highlighting the need for further pharmacokinetic optimization and clinical research to better understand its potential role in TB treatment

Molecular Formulas: CHNO (BPC-157)

Similarly, inhibition of PI3K/Akt signalling, which extends lifespan in model organisms, also prevents chemotherapy-induced ovarian depletion (Kalich-Philosoph et al, 2013)

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