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Fentanyl addiction can be hazardous, as the drug is powerful and can cause respiratory depression, overdose, and death

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used VPA, Parnate, TTNPB, and Dznep combining with other small molecules to induce direct reprogramming from MEFs to iHeps with only a single factor FOXA3 (Guo et al., 2017)

Not intended for human or animal use, ingestion, or injection

Filtration removes some contaminants but doesn't sterilize

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 40% by weight of the povidone