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Evidence of secondary coenzyme Q 10 deficiency has been reported in several mitochondrial disorders, such as mitochondrial DNA depletion syndrome, Kearns-Sayre syndrome, or multiple acyl-CoA dehydrogenase deficiency (MADD) (10)

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Small imbalances or weaknesses anywhere in this system create compensatory patterns that perpetuate injury

However, the authors concluded that the higher dose of HFC combined with MSM was crucial for the improvement in skin hydration

Doctors need to think about these differences when planning treatment

10.1016/j.redox.2021.102065 241 YokoyamaY.EstokT