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The Journal of the American Osteopathic Association

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During angiogenesis, VEGFR2 combines with VEGF to form dimers that activate receptor tyrosine kinase, and proceed with the downstream signal transduction by activating some protein kinases, such as p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) 1/2, and Akt protein kinase, to induce angiogenesis 32