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Adding GIP (the tirzepatide model) deepens the effect and, somewhat counterintuitively, appears to improve gastrointestinal tolerability relative to GLP-1 alone

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Theres no established upper limit

Pharmaceuticals, 18(2), 185.

FIGURE 3 2.1.4 PTT combined with other therapeutic agents Various studies have shown that the unique 2D structure of nanosheets makes them ideal for drug loading, and the functional groups connected to the vast surface area may be used to anchor other bioactive molecules