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PMID 30717170

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This combination makes it a so-called triple agonist , with each of these receptors involved in the regulation of metabolism, energy expenditure, and glucose homeostasis

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Molecular Medicine, 19(1), 334345

Warmly Dr Jill I appreciate the response, and perhaps you are the exception to my view of functional/integrative/alternative medicine doctors, but even with a fairly straightforward situation (homozygous a1298c but none of the other problematic methylation SNPs one reads about), I cant seem to get a coherent recommendation