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One big thing that can get in the way is tobacco use

Global Modern Oral Tobacco Market: SWOT Analysis 14

That being said, this was an eye opener for me

Flowering Tobacco is a fine choice for the garden, but it is also a good selection for planting in outdoor pots and containers

While Maxwell points out that pot does not appear to shrink the brain but may affect the brain in other ways, Hopfer notes that brain size isnt always associated with cognitive function

FDA used a similar line of reasoning in developing the tobacco rule when it concluded that banning tobacco products under the FFDCA's drug and device provisions was not an option