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10.1016/j.ecoenv.2022.114015 13 GuoY.ZhangN.ZhangD.RenQ.GanzT.LiuS.et al (2019)

The activation of the NLRP3 inflammasome leads to the secretion of pro-inflammatory cytokines such as interleukin-1 beta (IL-1) and IL-18, which causes the characteristic pain, redness, and swelling associated with gout

doi: 10.1172/JCI18181

Exploring associations among pro-inflammatory cytokines, osteoarthritis, and gut microbiome composition in individuals with obesity using machine learning

& Valle, D.) (McGraw-Hill, New York, USA, 2005)

The evolution of melatonin presumably occurred concurrently in both photosynthesizing cyanobacteria and in non-photosynthesizing bacteria, e.g., -proteobacteria, of which multiple types share a common ancestor (65)