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Furthermore, our data suggest an update of the current EDS nosology concerning scarring that should be considered separately from skin hyperextensibility and that the clinical diagnosis of cEDS may be enhanced by the accurate evaluation of orthopedic manifestations at all ages, faciocutaneous indicators in children, and some acquired traits related to joint instability complications, premature skin aging, and patterning of abnormal scarring in older individuals

"It's simple but tremendously important," Hoffmann said

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We had also an Irish ex-seminarian, belonging to the Dublin of James Joyce, who sported that delightful literary English of the educated Dubliner, with just the hint of the possibility of a brogue