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With the lung tissues damaged, the lungs ability to deliver oxygen-rich blood to the rest of the body has been permanently reduced

Tobacco use is estimated to kill more than eight million people globally each year, including about 1.3 million non-smokers who are exposed to second-hand smoke, World Health Organization (WHO) statistics show

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Such methodologies should allow for a direct comparison of (i) toxicant emissions, (ii) a broad range of toxicity endpoints and (iii) reductions in toxicant exposure, to ensure that a given cMRTP is equivalent to, or better than, the reference MRTP