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D-lactate is the optical isomer of L-lactate

A trial examining 40 women aged 40 to 65 demonstrated that topical GHK-Cu applied twice daily for 8 weeks reduced wrinkle volume by 55.8% and wrinkle depth by 32.8%

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Although uterine expression levels of estrogen receptor , G protein-coupled estrogen receptor, and steroid synthase were upregulated in the high-dose group, the decreased expression of connexin 43 and alkaline phosphatase as well as the increased expression of insulin-like growth factor-binding protein three and monoamine oxidase were consistent with decreased estrogen signaling and lower uterine weights