[DOI] [PubMed] [Google Scholar] [160].Sturniolo GC, Di Leo V, Ferronato A, DOdorico A, DInca R
83 While restriction of fruits and vegetables certainly plays a role in vitamin C deficiency, patients with IBD have been found to have polymorphisms in vitamin C transporter genes and tumor necrosis factor alpha (TNFa), an important inflammatory cytokine in IBD, which downregulates the transcription of vitamin C transporters, further reducing the capacity for vitamin C uptake
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Whether the selectivity observed in animals translates perfectly to humans is assumed but not rigorously proven across dose ranges
V.FehringerM.InnocentiG.VoglT
Dulaglutide: first global approval