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Rickettsia have highly reduced genomes with degraded biosynthetic pathways, including the loss of enzymes required for glycolysis, as well as biosynthesis of fatty acids, isoprenoids, vitamins, cofactors and amino acids, and the abundant low molecular weight thiol glutathione (GSH) 5,10,12
Along with its known function combating oxidative stress, GSH is also important for the detoxification of xenobiotics and metabolites, the regulation of cell growth and cell death, the regulation of the nitric oxide cycle, the storage of cysteine, the maintenance of redox potential and the modulation of immune function