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WADAs Summary of Major Modifications and Explanatory Notes is available and weve explained the major changes, as well as some of the minor clarifications, below

Resveratrol is a polyphenolic flavonoid, derived from grapes, mulberries, red wine, seeds, tea (green and black tea), and peanuts [75]

Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels

A structure-based assignment of the glutathione activator site without transition-state analogues is much more difficult because of labile GSH interactions 2 that likely depend not only on the presence of the first glutathione moiety but also on conformational changes of the glutathionylated enzyme 3,12,37,44

PMID 2646197