Creatine supplementation has been shown to down-regulate the synthesis of l-arginine : glycine amidinotransferase and consequently reduce endogenous formation of creatine, changing the methylation flux and reducing Hcy synthesis ( Reference Taes, Delanghe and De Vriese 6 , Reference Stead, Au and Jacobs 20 )
Its been a game-changer for me.
A problem arises when some poorly behaved toxin doesnt follow the rules and actually becomes more toxic during part of the detoxification process
The options were limited, often overpriced, and lacked transparency around quality and formulation
Effects noticeable within 1-2 weeks regarding pain relief and inflammation reduction, complete recovery takes 4-6 weeks
It must come from diet or supplementation