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Despite its well-defined mechanisms, curcumins low bioavailability and rapid metabolic clearance limit its clinical efficacy, prompting ongoing efforts to improve its formulation through nanocarriers, prodrug strategies, or bioenhancers

Standard glutathione capsules have a significantly different absorption profile

82,83 GPX1 is shown to promote proinammatory cytokine production and neutrophilia in response to endotoxin, 84 and to contribute to the development of ovalbumin-induced allergic asthma

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Funding The author(s) declare that financial support was received for the research, authorship, and/or publication of this article

Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG , Fang B