Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Tirz initiation Weeks 1-4 Tirzepatide 2.5 mg/week Cagrilintide Not started Notes Confirm tirzepatide GI tolerance first
Long et al., 2024), including the NADPH/FSP1/CoQ10 pathway, the dihydroorotate dehydrogenase (DHODH) pathway, the GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) pathway, the membrane-bound O-acyltransferase 1/2 (MBOAT1/2) pathway, the peroxiredoxin 6 (PRDX6) pathway, and the 7-dehydrocholesterol (7-DHC) pathway
VD obtained by sunlight exposure or through diet is converted to the main circulating form of VD, 25(OH)D, by 25 hydroxylase
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Cagrilintide plus semaglutide for obesity management
doi: 10.1016/j.hepres.2006.03.009 161