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An individuals ability to metabolize 90% of currently used drugs is largely determined by the genetic expression of these enzymes

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that when administered by continuous inhalation for 1 hour is likely to cause death within 14 days in half of the test animals

Humans take a more active approach, deliberately harnessing the cognitive performanceenhancing properties of many psychoactive plantsthose containing nicotine and caffeine (Einther and Giesbrecht Reference Einther and Giesbrecht2013